Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines.

Author(s): Massi P, Vaccani A, Ceruti S, Colombo A, Abbracchio MP, Parolaro D

Department of Pharmacology, University of Milan, Milan, Italy

Subject: Cancer View the study

Abstract:

Recently, cannabinoids (CBs) have been shown to possess antitumor properties. Because the psychoactivity of cannabinoid compounds limits their medicinal usage, we undertook the present study to evaluate the in vitro antiproliferative ability of cannabidiol (CBD), a nonpsychoactive cannabinoid compound, on U87 and U373 human glioma cell lines. The addition of CBD to the culture medium led to a dramatic drop of mitochondrial oxidative metabolism [3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H tetrazolium bromide test] and viability in glioma cells, in a concentration-dependent manner that was already evident 24 h after CBD exposure, with an apparent IC(50) of 25 microM...

Source: Journal of Pharmacology and Experimental Therapeutics
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