Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug.

Author(s): Zuardi AW, Crippa JA, Hallak JE, Moreira FA, Guimarães FS

Departamento de Neurologia, Psiquiatria e Psicologia Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil. [email protected]

Subject: Schizophrenia View the study

Abstract:

A high dose of delta9-tetrahydrocannabinol, the main Cannabis sativa (cannabis) component, induces anxiety and psychotic-like symptoms in healthy volunteers. These effects of delta9-tetrahydrocannabinol are significantly reduced by cannabidiol (CBD), a cannabis constituent which is devoid of the typical effects of the plant. This observation led us to suspect that CBD could have anxiolytic and/or antipsychotic actions. Studies in animal models and in healthy volunteers clearly suggest an anxiolytic-like effect of CBD.

Source: Brazilian Journal of Medical and Biological Research
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