Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances.

Author(s): Ren Y, Whittard J, Higuera-Matas A, Morris CV, Hurd YL

Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029-6574, USA

Subject: Addiction View the study

Abstract:

There remains debate regarding the impact of cannabis on neuropsychiatric disorders. Here, we examined the effects of cannabidiol (CBD), a nonpsychoactive constituent of cannabis, on heroin self-administration and drug-seeking behavior using an experimental rat model. CBD (5-20 mg/kg) did not alter stable intake of heroin self-administration, extinction behavior, or drug seeking induced by a heroin prime injection.

Source: Author Manuscript
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