Cannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats.

Author(s): Gururajan A, Taylor DA, Malone DT

Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia. [email protected]

Subject: ADD/ADHD View the study

Abstract:

Recently, a novel paradigm has been designed to assess social investigative behaviour in pairs of Sprague-Dawley rats, which involves physical separation whilst ensuring they are able to maintain contact through other social cues. We have modified this set-up in order to assess not just social behaviour but also locomotor activity of the rats. Results showed that the MK-801- (0.3 mg/kg) treated rats displayed reduced social investigative behaviour, hyperactivity as well as reduced attention span. Pretreatment with the phytocannabinoid cannabidiol (3 mg/kg) not only normalised social investigative behaviour but increased it beyond control levels.

Source: Journal of Psychopharmacology (Price: $40)
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