Subject: Epilepsy View the study
A comparison of the anticonvulsant and neurotoxic effects of cannabidiol (CBD), delta 9tetrahydrocannabinol, cannabinol and antiepileptic drugs (phenytoin, phenobarbital, carbamazepine, chlordiazepoxide, clonazepam, ethosuximide and trimethadione) was made in rats. Median effective potencies (ED 50 values) for maximal electroshock, audiogenic seizures and TD50 values for a rotor rod neurotoxicity test were calculated. Additionally, the interactive effects of CBD and the antiepileptic drugs against maximal electroshock and audiogenic seizures were studied.
Published via ACS Chemical Neuroscience
Published via Pharmacology
Published via Journal of Pharmacology and Experimental Therapeutics
Published via Pediatric Neurology
Published via European Journal of Epilepsy
Published via Pharmacological Reports