Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.

Author(s): McAllister SD, Christian RT, Horowitz MP, Garcia A, Desprez PY

California Pacific Medical Center, Research Institute, 475 Brannan Street, San Francisco, CA 94107, USA. [email protected]

Subject: Cancer View the study

Abstract:

Invasion and metastasis of aggressive breast cancer cells is the final and fatal step during cancer progression, and is the least understood genetically. Clinically, there are still limited therapeutic interventions for aggressive and metastatic breast cancers available. Clearly, effective and nontoxic therapies are urgently required. Id-1, an inhibitor of basic helix-loop-helix transcription factors, has recently been shown to be a key regulator of the metastatic potential of breast and additional cancers...

Source: Molecular Cancer Therapeutics
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