Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo.

Author(s): Jones NA, Hill AJ, Smith I, Bevan SA, Williams CM, Whalley BJ, Stephens GJ

School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6AJ, UK

Subject: Epilepsy View the study

Abstract:

Plant-derived cannabinoids (phytocannabinoids) are compounds with emerging therapeutic potential. Early studies suggested that cannabidiol (CBD) has anticonvulsant properties in animal models and reduced seizure frequency in limited human trials. Here, we examine the antiepileptiform and antiseizure potential of CBD using in vitro electrophysiology and an in vivo animal seizure model, respectively. CBD (0.01-100 muM) effects were assessed in vitro using the Mg(2+)-free and 4-aminopyridine (4-AP) models of epileptiform activity in hippocampal brain slices via multielectrode array recordings.

Source: Journal of Pharmacology and Experimental Therapeutics
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