Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1.

Author(s): Ramer R, Bublitz K, Freimuth N, Merkord J, Rohde H, Haustein M, Borchert P, Schmuhl E, Linnebacher M, Hinz B

Institute of Toxicology and Pharmacology, Department of General Surgery, University of Rostock, Schillingallee 70, D-18057 Rostock, Germany

Subject: Cancer View the study

Abstract:

Cannabinoids inhibit cancer cell invasion via increasing tissue inhibitor of matrix metalloproteinases-1 (TIMP-1). This study investigates the role of intercellular adhesion molecule-1 (ICAM-1) within this action. In the lung cancer cell lines A549, H358, and H460, cannabidiol (CBD; 0.001-3 μM) elicited concentration-dependent ICAM-1 up-regulation compared to vehicle via cannabinoid receptors, transient receptor potential vanilloid 1, and p42/44 mitogen-activated protein kinase...

Source: The FASEB Journal (Price: $20)
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