Cannabidiol Treatment for Refractory Seizures in Sturge-Weber Syndrome.

Author(s): Kaplan EH, Offermann EA, Sievers JW, Comi AM

Department of Neurology, Kennedy Krieger Institute, Baltimore, Maryland

Subject: Epilepsy View the study


BACKGROUND: Sturge-Weber syndrome results in leptomeningeal vascular malformations, medically refractory epilepsy, stroke(s), and cognitive impairments. Cannabidiol, a cannabinoid without psychoactive properties, has been demonstrated in preclinical models to possibly have anticonvulsant, antioxidant, and neuroprotective actions. METHODS: Five subjects with Sturge-Weber syndrome brain involvement and treatment-resistant epilepsy were enrolled. Motor seizure frequency, quality of life, and adverse events were recorded from the eighth week of the pretreatment period, eight weeks after starting maintenance dose (week 14), and the most recent visit.

Source: Pediatric Neurology (Price: $36)
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