Cannabinoid modulation of fear extinction brain circuits: a novel target to advance anxiety treatment.

Author(s): Rabinak CA, Phan KL

Department of Psychiatry, University of Michigan, Rachel Upjohn Building, 4250 Plymouth Road, Ann Arbor, MI 48109-2700. [email protected]

Subject: PTSD View the study


Anxiety disorders, such as post-traumatic stress (PTSD), panic, and phobic disorders, can be conceptualized as a failure to inhibit inappropriate fear responses. A common, effective treatment strategy involves repeated presentations to the feared cue without any danger (extinction). However, extinction learning has a number of important limitations, and enhancing its effects, generalizability and durability via cognitive enhancers may improve its therapeutic impact. In this review we focus specifically on the role of the cannabinoid system in fear extinction learning and its retention.

Source: Current Pharmaceutical Design (Price: $58)
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