COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells.

Author(s): Ramer R, Heinemann K, Merkord J, Rohde H, Salamon A, Linnebacher M, Hinz B

Institute of Toxicology and Pharmacology, University of Rostock, Rostock, Germany

Subject: Cancer View the study

Abstract:

The antitumorigenic mechanism of cannabidiol is still controversial. This study investigates the role of COX-2 and PPAR-γ in cannabidiol's proapoptotic and tumor-regressive action. In lung cancer cell lines (A549, H460) and primary cells from a patient with lung cancer, cannabidiol elicited decreased viability associated with apoptosis. Apoptotic cell death by cannabidiol was suppressed by NS-398 (COX-2 inhibitor), GW9662 (PPAR-γ antagonist), and siRNA targeting COX-2 and PPAR-γ...

Source: Molecular Cancer Therapeutics
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