Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats.

Author(s): Hine B, Torrelio M, Gershon S

Subject: Addiction View the study


The same dose of cannabinol (CBN) or cannabidiol (CBD) further increased the attenuation of precipitated abstinence signs observed in morphine-dependent rats that also received an acute dose of delta 9-THC. By contrast, rotational behavior (turning), which is observed concomitantly in THC-treated rats during morphine abstinence, was not increased by CBN, but was potentiated by CBD.

Source: Research Communications in Chemical Pathology and Pharmacology
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