Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress.

Author(s): Hill MN, Patel S, Carrier EJ, Rademacher DJ, Ormerod BK, Hillard CJ, Gorzalka BB

Department of Psychology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4

Subject: Stress View the study

Abstract:

Deficits in cognitive functioning and flexibility are seen following both chronic stress and modulation of endogenous cannabinoid (eCB) signaling. Here, we investigated whether alterations in eCB signaling might contribute to the cognitive impairments induced by chronic stress. Chronic stress impaired reversal learning and induced perseveratory behavior in the Morris water maze without significant effect on task acquisition. These cognitive impairments were reversed by exogenous cannabinoid administration, suggesting deficient eCB signaling underlies these phenomena.

Source: Neuropsychopharmacology
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