Endocannabinoids and stress.

Author(s): Riebe CJ, Wotjak CT

Max Planck Institute of Psychiatry Munich, Germany

Subject: Stress View the study


Endogenous cannabinoids play an important role in the physiology and behavioral expression of stress responses. Activation of the hypothalamic-pituitary-adrenal (HPA) axis, including the release of glucocorticoids, is the fundamental hormonal response to stress. Endocannabinoid (eCB) signaling serves to maintain HPA-axis homeostasis, by buffering basal activity as well as by mediating glucocorticoid fast feedback mechanisms. Following chronic stressor exposure, eCBs are also involved in physiological and behavioral habituation processes.

Source: Stress (Price: $54)
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