Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output.

Author(s): Hill MN, Patel S, Campolongo P, Tasker JG, Wotjak CT, Bains JS

Laboratory of Neuroendocrinology, The Rockefeller University, New York, New York 10065, USA. [email protected]

Subject: Stress View the study

Abstract:

Endocannabinoid signaling is distributed throughout the brain, regulating synaptic release of both excitatory and inhibitory neurotransmitters. The presence of endocannabinoid signaling within stress-sensitive nuclei of the hypothalamus, as well as upstream limbic structures such as the amygdala, suggests it may play an important role in regulating the neuroendocrine and behavioral effects of stress. The evidence reviewed here demonstrates that endocannabinoid signaling is involved in both activating and terminating the hypothalamic-pituitary-adrenal axis response to both acute and repeated stress.

Source: Author Manuscript
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