Modulation of fear memory by dietary polyunsaturated fatty acids via cannabinoid receptors.

Author(s): Yamada D, Takeo J, Koppensteiner P, Wada K, Sekiguchi M

Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan [2] CREST, Japan Science and Technology Agency, Kawaguchi, Saitama, Japan

Subject: PTSD View the study


Although the underlying mechanism remains unknown, several studies have suggested benefits of n-3 long-chain polyunsaturated fatty acid (PUFA) for patients with anxiety disorders. Elevated fear is thought to contribute to the pathogenesis of particular anxiety disorders. The aim of the present study was to evaluate whether the dietary n-3 to n-6 PUFA (3:6) ratio influences fear memory. For this purpose, the effects of various dietary 3:6 ratios on fear memory were examined in mice using contextual fear conditioning, and the effects of these diets on central synaptic transmission were examined to elucidate the mechanism of action of PUFA.

Source: Neuropsychopharmacology
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