Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture.

Author(s): Deng L, Ng L, Ozawa T, Stella N

Departments of Pharmacology, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington (L.D., L.N., N.S.); Department of Neurosurgery, Alvord Brain Tumor Center, University of Washington, Seattle, Washington (T.O.); and Division of Human Biology and Solid Tumor Translational Research, Fred Hutchinson Cancer Research Center, Seattle, Washington (T.O.) / Departments of Pharmacology, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington (L.D., L.N., N.S.); Department of Neurosurgery, Alvord Brain Tumor Center, University of Washington, Seattle, Washington (T.O.); and Division of Human Biology and Solid Tumor Translational Research, Fred Hutchinson Cancer Research Center, Seattle, Washington (T.O.) [email protected]

Subject: Cancer View the study

Abstract:

Evidence suggests that the nonpsychotropic cannabis-derived compound, cannabidiol (CBD), has antineoplastic activity in multiple types of cancers, including glioblastoma multiforme (GBM). DNA-damaging agents remain the main standard of care treatment available for patients diagnosed with GBM. Here we studied the antiproliferative and cell-killing activity of CBD alone and in combination with DNA-damaging agents (temozolomide, carmustine, or cisplatin) in several human GBM cell lines and in mouse primary GBM cells in cultures.

Source: Journal of Pharmacology and Experimental Therapeutics (Price: $25)
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