Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders.

Author(s): Gorzalka BB, Hill MN, Hillard CJ

Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, BC, Canada V6T1Z4. [email protected]

Subject: Stress View the study


The endocannabinoid system is a widely distributed, neuromodulatory system which serves an integral role in regulating synaptic transmission. The presence of this system in stress-responsive neural circuits suggests that it may play a critical role in regulating neuroendocrine and behavioral responses to stress. Endocannabinoid content in limbic structures which regulate activation of the hypothalamic-pituitary-adrenal (HPA) axis is dynamically regulated by stress.

Source: Neuroscience & Biobehavioral Reviews (Price: $36)
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