Searching for a neurobiological basis for self-medication theory in ADHD comorbid with substance use disorders: an in vivo study of dopamine transporters using (99m)Tc-TRODAT-1 SPECT.

Author(s): Silva N Jr, Szobot CM, Shih MC, Hoexter MQ, Anselmi CE, Pechansky F, Bressan RA, Rohde LA

From the *Laboratório de Medicina Nuclear do Complexo Hospitalar Santa Casa (LAMENU), Porto Alegre

Subject: ADD/ADHD View the study


Attention-deficit/hyperactivity disorder (ADHD) and substance use disorders (SUD) frequently co-occur. Although several studies have shown changes in striatal dopamine transporter (DAT) density in these disorders, little is known about the neurobiological basis of the comorbidity. The aim of this study was to evaluate striatal DAT density in treatment-naive ADHD adolescents with SUD (ADHD + SUD) and without SUD (ADHD), compared to SUD adolescents without ADHD (SUD) and healthy control subjects (HC).

Source: Clinical Nuclear Medicine (Price: $49)
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