Seizing an opportunity for the endocannabinoid system.

Author(s): Alger BE

Departments of Physiology and Psychiatry, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD

Subject: Epilepsy View the study

Abstract:

Exogenous cannabinoids can limit seizures and neurodegeneration, and their actions are largely mimicked by endogenous cannabinoids (endocannabinoids). Endocannabinoids are mobilized by epileptiform activity and in turn influence this activity by inhibiting synaptic transmission; both excitatory and some inhibitory synapses can be suppressed, leading to potentially complex outcomes.

Source: Epilepsy Currents
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