Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis.

Author(s): Glangetas C, Girard D, Groc L, Marsicano G, Chaouloff F, Georges F

UMR 5297 CNRS, Institut Interdisciplinaire de NeuroScience, Development and Adaptation of Neuronal Circuits, Bordeaux F-33076, France, Université Bordeaux Segalen, Bordeaux F-33076, France, and INSERM, U862, Neurocentre Magendie, Pathophysiology of Neuronal Plasticity, Bordeaux F-33076, France

Subject: PTSD View the study


The bed nucleus of the stria terminalis (BNST) exerts a coordinated modulation of the psychoneuroendocrine responses to stress. However, how acute stress impacts on BNST in vivo plasticity is a crucial question that still remains unanswered. Here, neurons from the anterior portion of the BNST (aBNST) were recorded in vivo during and after stimulation of their medial prefrontal cortical (mPFC) afferents. In C57BL/6N mice, a 1 h restraint stress induced a switch from long-term depression (LTD) to long-term potentiation (LTP) in the aBNST after a 10 Hz mPFC stimulation.

Source: Journal of Neuroscience
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