The role of the endocannabinoid system in eating disorders: neurochemical and behavioural preclinical evidence.

Author(s): Scherma M, Fattore L, Castelli MP, Fratta W, Fadda P

Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato (Cagliari), Italy. [email protected]

Subject: Anorexia View the study


The endocannabinoid system has long been known as a modulator of several physiological functions, among which the homeostatic and hedonic aspects of eating. CB1 receptors are widely expressed in brain regions that control food intake, reward and energy balance. Animal and human studies indicate that CB1 receptor agonists possess orexigenic effects enhancing appetite and increasing the rewarding value of food. Conversely, CB1 antagonists have been shown to inhibit the intake of food. Eating disorders include a range of chronic and disabling related pathological illnesses that are characterized by aberrant patterns of feeding behaviour and weight regulation, and by abnormal attitudes and perceptions toward body shape image.

Source: Current Pharmaceutical Design (Price: $58)
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