Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents.

Author(s): Nabissi M, Morelli MB, Santoni M, Santoni G

Department of Experimental Medicine, School of Pharmacy, University of Camerino, Camerino, MC 62032, Italy

Subject: Cancer View the study

Abstract:

The aggressive behavior of Glioblastoma multiforme (GBM) is mainly due to high invasiveness and proliferation rate as well as to high resistance to standard chemotherapy. Several chemotherapeutic agents like temozolomide (TMZ), carmustine (BCNU) or doxorubicin (DOXO) have been employed for treatment of GBM, but they display limited efficacy. Therefore, it is important to identify new treatment modalities to improve therapeutic effects and enhance GBM chemosensitivity...

Source: Carcinogenesis
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